| pubmed-article:7588610 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7588610 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:7588610 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7588610 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7588610 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:7588610 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:7588610 | lifeskim:mentions | umls-concept:C0439659 | lld:lifeskim |
| pubmed-article:7588610 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7588610 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:7588610 | pubmed:dateCreated | 1995-11-28 | lld:pubmed |
| pubmed-article:7588610 | pubmed:abstractText | In budding yeast G1 cells increase in cell mass until they reach a critical cell size, at which point (called Start) they enter S phase, bud and duplicate their spindle pole bodies. Activation of the Cdc28 protein kinase by G1-specific cyclins Cln1, Cln2 or Cln3 is necessary for all three Start events. Transcriptional activation of CLN1 and CLN2 by SBF and MBF transcription factors also requires an active Cln-Cdc28 kinase and it has therefore been proposed that the sudden accumulation of CLN1 and CLN2 transcripts during late G1 occurs via a positive feedback loop. We report that whereas Cln1 and Cln2 are required for the punctual execution of most, if not all, other Start-related events, they are not required for the punctual activation of SBF- or MBF-driven transcription. Cln3, on the other hand, is essential. By turning off cyclin B proteolysis and turning on proteolysis of the cyclin B-Cdc28 inhibitor p40SIC1, Cln1 and Cln2 kinases activate cyclin B-Cdc28 kinases and thereby trigger S phase. Thus the accumulation of Cln1 and Cln2 kinases which starts the yeast cell cycle is set in motion by prior activation of SBF- and MBF-mediated transcription by Cln3-Cdc28 kinase. This dissection of regulatory events during late G1 demands a rethinking of Start as a single process that causes cells to be committed to the mitotic cell cycle. | lld:pubmed |
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| pubmed-article:7588610 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7588610 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7588610 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7588610 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7588610 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7588610 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:7588610 | pubmed:author | pubmed-author:NasmythKK | lld:pubmed |
| pubmed-article:7588610 | pubmed:author | pubmed-author:BöhmTT | lld:pubmed |
| pubmed-article:7588610 | pubmed:author | pubmed-author:DirickLL | lld:pubmed |
| pubmed-article:7588610 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7588610 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:7588610 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:7588610 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7588610 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7588610 | pubmed:pagination | 4803-13 | lld:pubmed |
| pubmed-article:7588610 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7588610 | pubmed:meshHeading | pubmed-meshheading:7588610-... | lld:pubmed |
| pubmed-article:7588610 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7588610 | pubmed:articleTitle | Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. | lld:pubmed |
| pubmed-article:7588610 | pubmed:affiliation | Research Institute of Molecular Pathology, Vienna, Austria. | lld:pubmed |
| pubmed-article:7588610 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7588610 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
