Linked Life Data

7543542

Source:http://linkedlifedata.com/resource/pubmed/id/7543542

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-9-8
pubmed:abstractText
CTL activity is a major component of the host immune response associated with control of HIV replication in the course of infection. Emerging populations of HIV overcome the protective effector mechanisms with variant sequences unrecognized by CTL. Therefore, a critical element for containment of virus spread might be the establishment of an immune response against highly conserved epitopes. In this study, we selected a panel of nonamer or decamer peptides, with demonstrated binding affinity for HLA-A 0201, to define novel highly conserved envelope-derived epitopes of HIV-1. CTL activities were characterized from PBMC of five HLA-A2+, HIV-1-infected individuals given recombinant gp160. CTL activity derived from patient PBMC stimulated in vitro with peptide was demonstrated against at least two novel minimal env-encoded conserved epitopes. One epitope, KLTPLCVTL (aa 120-128), is highly conserved among HIV-1 strains of the B subtype. Analysis of a CTL clone reactivity to a distinct epitope (aa 814-823) demonstrated fluctuations in the recognition of peptides corresponding to natural virus variants found in vivo.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
155
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2232-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Characterization of HLA-A 0201-restricted cytotoxic T cell epitopes in conserved regions of the HIV type 1 gp160 protein.
pubmed:affiliation
Center for AIDS Research, Stanford University, CA 94305, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't