Linked Life Data

7540847

Source:http://linkedlifedata.com/resource/pubmed/id/7540847

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-8-3
pubmed:abstractText
We examined the relationship between cardiac hypertrophy, myosin heavy chain (MHC) isoform expression, and production of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) before and after the development of DOCA-salt hypertension. DOCA-salt rats exhibited significant left ventricular hypertrophy at the prehypertensive stage (1 week of treatment), without MHC isoform switch or change in natriuretic peptide gene expression. In the hypertensive stage (5 weeks of treatment), pronounced left ventricular hypertrophy was observed, and this was characterized by an increase in beta-MHC protein, resulting in a switch from 90% alpha-MHC to 51% alpha-MHC and 49% beta-MHC. ANF and BNP mRNA levels and peptide content were significantly increased at this stage. Unexpectedly, the MHC isoform switch was evident in the non-hypertrophied right ventricle to the same degree as in the left ventricle. Natriuretic peptide production was also increased in the right ventricle at 5 weeks of treatment, but to a lesser degree than in the left ventricle. In contrast, in the hypertrophied left atrium there was no MHC isoform switch, while ANF and BNP mRNA levels were augmented. Plasma ANF was significantly increased in the prehypertensive stage; this was accompanied by a partial depletion of atrial ANF stores. Plasma BNP was increased only in the hypertensive stage, reflecting an increase in ventricular BNP synthesis and secretion. These results suggest that 1) cardiac hypertrophy, MHC isoform expression, and stimulation of natriuretic peptide production are processes that may be dissociated from each other; 2) increases in plasma ANF without a concomitant increase in plasma BNP reflect atrial hemodynamic overload, while increases in both ANF and BNP in plasma are associated with ventricular hypertrophy; and 3) there exist differences in the storage, secretion, and processing patterns of ANF and BNP in the atria.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0895-7061
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-10
pubmed:dateRevised
2009-2-24
pubmed:meshHeading
pubmed-meshheading:7540847-Animals, pubmed-meshheading:7540847-Atrial Natriuretic Factor, pubmed-meshheading:7540847-Blood Pressure, pubmed-meshheading:7540847-Blotting, Northern, pubmed-meshheading:7540847-Body Weight, pubmed-meshheading:7540847-Cardiomegaly, pubmed-meshheading:7540847-Centrifugation, Density Gradient, pubmed-meshheading:7540847-Chromatography, High Pressure Liquid, pubmed-meshheading:7540847-Desoxycorticosterone, pubmed-meshheading:7540847-Hypertension, pubmed-meshheading:7540847-Isomerism, pubmed-meshheading:7540847-Male, pubmed-meshheading:7540847-Myocardium, pubmed-meshheading:7540847-Myosin Subfragments, pubmed-meshheading:7540847-Natriuretic Peptide, Brain, pubmed-meshheading:7540847-Nerve Tissue Proteins, pubmed-meshheading:7540847-Organ Size, pubmed-meshheading:7540847-RNA, pubmed-meshheading:7540847-Radioimmunoassay, pubmed-meshheading:7540847-Rats, pubmed-meshheading:7540847-Rats, Sprague-Dawley, pubmed-meshheading:7540847-Sodium Chloride
pubmed:year
1995
pubmed:articleTitle
Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats.
pubmed:affiliation
University of Ottawa Heart Institute Research Centre, Ottawa Civic Hospital, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't