Linked Life Data

7508513

Source:http://linkedlifedata.com/resource/pubmed/id/7508513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-3-15
pubmed:abstractText
Automatic identification of the ribozyme core of group I catalytic introns in genomic sequences is shown to be feasible in spite of the scarcity of strictly conserved features in the sequence and secondary structure of group I introns. An algorithm is described that successfully identified 132 out of the 143 currently reported group I cores with a false positive rate of only 10(-6) per nucleotide. The recognition process consists in generating and rating large sets of potential local solutions which are gradually combined into more complex structures until an entire core (six to seven pairings, six connecting segments, three terminal loops) has been assembled. The extent to which successful recognition may be prevented by sequencing errors is assessed. Also discussed are (1) possible relationships between scores allocated by the program and ability to self-splice in vitro and (2) the potential for objectively assessing the degree of relatedness to group I of structures claimed to resemble group I introns.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-2836
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
235
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1206-17
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Automatic identification of group I intron cores in genomic DNA sequences.
pubmed:affiliation
Centre de Génétique Moléculaire du C.N.R.S., Laboratoire associé à l'Université Pierre et Marie Curie, Gif-sur-Yvette, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't