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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1996-1-16
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pubmed:abstractText |
1. Pepsin-digested form of OVA has approximately the same molecular weight as native OVA, but differs in charge and isoelectric focusing point. 2. Pepsin-treated OVA retains most of the native OVA T- and B-cell determinants. 3. Delayed-type hypersensitivity response is suppressed when pepsin-treated OVA is administered i.p. to naive mice. 4. Cimetidine treatment of mice prior to ingestion of OVA shows decreased tolerance, while oral administration of pepsin-treated OVA to cimetidine-treated mice leads to a complete immune unresponsiveness; this suggests an important role for gastric digestion in orally induced immune tolerance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0065-2598
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
371B
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1245-50
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:7502793-Administration, Oral,
pubmed-meshheading:7502793-Animals,
pubmed-meshheading:7502793-Antigens,
pubmed-meshheading:7502793-Cimetidine,
pubmed-meshheading:7502793-Digestion,
pubmed-meshheading:7502793-Female,
pubmed-meshheading:7502793-Gastric Juice,
pubmed-meshheading:7502793-Hydrogen-Ion Concentration,
pubmed-meshheading:7502793-Hypersensitivity, Delayed,
pubmed-meshheading:7502793-Immune Tolerance,
pubmed-meshheading:7502793-Immunity, Mucosal,
pubmed-meshheading:7502793-Lymphocyte Activation,
pubmed-meshheading:7502793-Male,
pubmed-meshheading:7502793-Mice,
pubmed-meshheading:7502793-Mice, Inbred C57BL,
pubmed-meshheading:7502793-Mice, Inbred DBA,
pubmed-meshheading:7502793-Ovalbumin,
pubmed-meshheading:7502793-Pepsin A,
pubmed-meshheading:7502793-Peyer's Patches,
pubmed-meshheading:7502793-T-Lymphocytes
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pubmed:year |
1995
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pubmed:articleTitle |
The influence of antigen digestion on orally induced immunity and tolerance.
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pubmed:affiliation |
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, OH 45267-0524, USA.
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pubmed:publicationType |
Journal Article
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