Linked Life Data

7402294

Source:http://linkedlifedata.com/resource/pubmed/id/7402294

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5765
pubmed:dateCreated
1980-10-27
pubmed:abstractText
Infection or inflammation triggers the rapid appearance in the blood of a group of proteins known as acute phase reactants. Serum amyloid A protein (SAA) is an acute phase protein which is believed to be the precursor for the secondary amyloid fibril protein, known previously as amyloid of unknown origin, and now as amyloid A protein (AA). The site of synthesis of SAA has been controversial, with previous evidence suggesting that AA related proteins arise in liver, connective tissues, polymorphonuclear neutrophil leukocytes and spleen. However, in none of these systems could SAA synthesis be induced in vitro and the evidence rested on studies of tissues or cells arising from pre-stimulated animals. Our aim in the present studies was to prove that the liver is capable of SAA production and to identify the specific cell responsible for synthesis. The experiments demonstrate that SAA is synthesized in the liver by hepatocytes. In addition, colchicine, currently used for the treatment of amyloidosis, blocks the secretion of SAA from the hepatocyte, as has been shown for another acute phase reactan, C-reactive protein.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
285
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
498-500
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Monokine-induced synthesis of serum amyloid A protein by hepatocytes.
pubmed:publicationType
Journal Article