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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1980-9-23
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pubmed:abstractText |
We report the characterization of a monoclonal antibody which detects a surface antigen expressed by the bone marrow target cell of A-MuLV. Treatment of bone marrow cells with this antibody and complement results in greater than loss 95% loss of the A-MuLV-derived in vitro transformed foci. The surface antigen detected by this antibody is also expressed on A-MuLV-transformed lymphoid cell lines, thymocytes, and some peripheral lymphocytes. This antigen is not expressed, however, by the pluripotent hematopoietic stem cell defined by the spleen colony-forming assay. We present evidence that the antigen detected is neither a virally encoded product, nor exclusively associated with the BALB/c genome.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7388941-Abelson murine leukemia virus,
pubmed-meshheading:7388941-Animals,
pubmed-meshheading:7388941-Antibody Specificity,
pubmed-meshheading:7388941-Antigens, Neoplasm,
pubmed-meshheading:7388941-Antigens, Surface,
pubmed-meshheading:7388941-Bone Marrow,
pubmed-meshheading:7388941-Bone Marrow Cells,
pubmed-meshheading:7388941-Brain,
pubmed-meshheading:7388941-Cell Transformation, Viral,
pubmed-meshheading:7388941-Clone Cells,
pubmed-meshheading:7388941-Hematopoietic Stem Cells,
pubmed-meshheading:7388941-Lymphocytes,
pubmed-meshheading:7388941-Mice,
pubmed-meshheading:7388941-Viral Proteins
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pubmed:year |
1980
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pubmed:articleTitle |
Monoclonal rat anti-mouse brain antibody detects Abelson murine leukemia virus target cells in mouse bone marrow.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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