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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1980-3-24
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pubmed:abstractText |
Gentamicin half-life values based on pharmacologic calculations were determined in 23 infants and children with diminished renal function. The half-life times correlated significantly with serum creatinine concentrations in patients who had steady-state creatinine levels (Y = 0.379 + 3.841 X, R = 0.951, P less than 0.001). This relationship provides a basis for formulating gentamicin dosage in pediatric patients with renal failure. The half-life of gentamicin is estimated by multiplying the serum creatinine concentration by four; three-quarters of the loading dose is administered every two half-lives. When renal function is unstable and changing daily, gentamicin half-life cannot be reliably predicted from the serum creatinine value.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-3476
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
331-4
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7351608-Bacterial Infections,
pubmed-meshheading:7351608-Child,
pubmed-meshheading:7351608-Child, Preschool,
pubmed-meshheading:7351608-Creatinine,
pubmed-meshheading:7351608-Gentamicins,
pubmed-meshheading:7351608-Half-Life,
pubmed-meshheading:7351608-Humans,
pubmed-meshheading:7351608-Infant,
pubmed-meshheading:7351608-Infant, Newborn,
pubmed-meshheading:7351608-Kidney Failure, Chronic
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pubmed:year |
1980
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pubmed:articleTitle |
Determining gentamicin dosage in infants and children with renal failure.
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pubmed:publicationType |
Journal Article
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