Linked Life Data

7311565

Source:http://linkedlifedata.com/resource/pubmed/id/7311565

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-2-22
pubmed:abstractText
Respiratory responses to a variety of known bronchoactive agents were compared in anesthetized rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) monkeys. Administration of 0.1 to 1.0% histamine aerosols resulted in an increase in airway resistance of 50 to 200% and a decrease in lung compliance of 30 to 80%. Aerosols of prostaglandin E2 (1 mg/ml), terbutaline (10 mg/ml), and isoproterenol (10 mg/ml) or iv aminophylline (up to 7.0 mg/kg) administered concomitantly with histamine produced a transient reversal of the histamine-induced changes in both species. Since the rhesus and cynomolgus monkeys responded in a comparable manner to these bronchodilator agents, the cynomolgus monkey appears to be an additional valuable model for the evaluation of potential bronchoactive compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0160-5402
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
267-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
A comparative study of the respiratory responses to bronchoactive agents in rhesus and cynomolgus monkeys.
pubmed:publicationType
Journal Article, Comparative Study