Linked Life Data

7223452

Source:http://linkedlifedata.com/resource/pubmed/id/7223452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-6-25
pubmed:abstractText
The blocking (endoanesthetic) effects of lidocaine (Xylocaine) and benzonatate (Tessalon) on cardiac ventricular, non-medullated endings were tested in cats. Lidocaine was found to cause an effective and long-lasting partial blockade of the cardiovascular reflex responses to stimulation of the ventricular receptors. This effect was obtained at plasma concentrations of 2.5-4.7 microgram/ml, which is within the concentration range seen in patients with myocardial infarction treated with lidocaine because of its antiarrhythmic properties. Tessalon also markedly attenuated the reflex response, normally obtained when the ventricular receptors are excited, but the effect was very shortlasting when doses, producing no side effects, were used. Recordings of impulse traffic from the left ventricular receptors showed that the impaired reflex responses after lidocaine and Tessalon were due to a blockade at the receptor level. Thus both the receptor response to ventricular distension and to injection of protoveratrine (Bezold-Jarisch reflex) was markedly attenuated after infusion of lidocaine (2-4 mg/kg) or a bolus injection of Tessalon (0.2-1 mg/kg).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0001-6772
pubmed:author
pubmed:issnType
Print
pubmed:volume
111
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Studies on the endoanesthetic effects of lidocaine and benzonatate on non-medullated nerve endings in the left ventricle.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't