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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1983-2-14
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pubmed:abstractText |
A six week course of cimetidine (1 g/day) healed peptic ulcers in 20 of 23 patients (14 with duodenal ulcer, nine with gastric ulcer). Reduction of basal acid output by 73% and peak acid output by 36% led to a rise in concentrations of intragastric aerobic bacteria and nitrate-reducing bacteria. While the mean intragastric concentration of nitrate was unchanged by treatment, there were statistically significant rises in nitrite and N-nitrosamine concentrations. The conversion from nitrates to nitrites was closely related to the occurrence of nitrate-reducing bacteria. In three patients the intragastric milieu had returned to normal two months after cimetidine treatment had been discontinued. Mean nitrite and N-nitrosamine concentrations did not return to pre-treatment levels in the group of eight patients who remained on maintenance cimetidine (0.4 g at night-time) for three months after the full dose treatment. This study shows that cimetidine treatment can create an intragastric milieu resembling that of atrophic gastritis. Large scale and long-term studies are necessary to establish whether these findings have any clinical significance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-13831394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-14383972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-2870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-4361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-4850688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-4885396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-5435146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-6103090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-6105357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-6110040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-62896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-633950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-736263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-73641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-7371479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-76069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-76225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-86721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-87691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7173716-892343
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1048-54
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7173716-Adult,
pubmed-meshheading:7173716-Bacteria,
pubmed-meshheading:7173716-Cimetidine,
pubmed-meshheading:7173716-Female,
pubmed-meshheading:7173716-Gastric Acid,
pubmed-meshheading:7173716-Guanidines,
pubmed-meshheading:7173716-Humans,
pubmed-meshheading:7173716-Hydrogen-Ion Concentration,
pubmed-meshheading:7173716-Male,
pubmed-meshheading:7173716-Middle Aged,
pubmed-meshheading:7173716-Nitrates,
pubmed-meshheading:7173716-Nitrites,
pubmed-meshheading:7173716-Nitrosamines,
pubmed-meshheading:7173716-Peptic Ulcer,
pubmed-meshheading:7173716-Stomach
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pubmed:year |
1982
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pubmed:articleTitle |
Intragastric nitrites, nitrosamines, and bacterial overgrowth during cimetidine treatment.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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