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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1983-4-15
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pubmed:abstractText |
Succinylacetone was shown to inhibit aminolevulinate dehydratase (5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), EC 4.2.1.24) to reduce cellular heme and porphyrins and to induce delta-aminolevulinate synthase (succinyl-CoA:glycine C-succinyltransferase (decarboxylating), EC 2.3.1.37) in monolayers of chick embryo liver cells. Marked synergistic effects on delta-aminolevulinate synthase activity were obtained by combining succinylacetone with levulinate and porphyrogenic drugs. The time course of delta-aminolevulinate synthase activity showed a delayed synergistic response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
721
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
408-17
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7159602-5-Aminolevulinate Synthetase,
pubmed-meshheading:7159602-Allylisopropylacetamide,
pubmed-meshheading:7159602-Animals,
pubmed-meshheading:7159602-Cells, Cultured,
pubmed-meshheading:7159602-Chick Embryo,
pubmed-meshheading:7159602-Drug Synergism,
pubmed-meshheading:7159602-Enzyme Induction,
pubmed-meshheading:7159602-Heme,
pubmed-meshheading:7159602-Heptanoates,
pubmed-meshheading:7159602-Heptanoic Acids,
pubmed-meshheading:7159602-Levulinic Acids,
pubmed-meshheading:7159602-Liver,
pubmed-meshheading:7159602-Porphobilinogen Synthase
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pubmed:year |
1982
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pubmed:articleTitle |
The effects of succinylacetone (4,6-dioxoheptanoic acid) on delta-aminolevulinate synthase activity and the content of heme in monolayers of chick embryo liver cells.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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