Linked Life Data

7157398

Source:http://linkedlifedata.com/resource/pubmed/id/7157398

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1983-3-17
pubmed:abstractText
Teratogenic effects of a single subcutaneous dose of ochratoxin A (1.75 mg/kg) on one of gestation days 4-10 has been studied in rats. Treatment on days 4, 5, 6 or 7 resulted in increased fetal resorptions, and decreased fetal weights. Fetal weights also were depressed after treatment on day 8. The highest number of resorptions, greatest depression of fetal weights and largest number of malformations occurred when ochratoxin A was injected on days 5, 6 or 7. External hydrocephaly, omphalocele, and anophthalmia were the major gross anomalies. Internal hydrocephaly and shift in position of esophagus were the main internal soft tissue defects. Major skeletal defects involved sternebrae, vertebrae and ribs. Subcutaneous injection of 1.75 mg/kg ochratoxin A seemed to be the minimum effective, single teratogenic dose. Lower doses (0.5 or 1.0 mg/kg) failed to produce any embryotoxicity or malformations and higher doses (e.g. 5.0 mg/kg) caused all fetuses to be resorbed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-85
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Embryocidal, fetotoxic and teratogenic effects of ochratoxin A in rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.