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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1983-3-11
|
| pubmed:abstractText |
The EMT6 tumor of Balb/C mice was studied in vivo for irradiation response. It showed a typical, progressive Gompertzian growth mode in control tumors, and, after irradiation with 2000, 4000 or 6000 rad, a regression and regrowth pattern. This solid tumor model was studied with serial DNA-polymerase (DNA-P) alpha and B assays after irradiation-perturbed growth. The DNA-P activity was traced during growth and injury-regrowth to study its behavior as a potential marker for tumor activity. DNA-P alpha level fell after high dose irradiation, remained low during the early regeneration period, and rose again after a regrowth pattern was established. The changes in activity followed DNA-S activity by H3TDR uptake. DNA-P B activity did not change after irradiation.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0305-7232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
109-17
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1982
|
| pubmed:articleTitle |
DNA polymerases in irradiated regressing or regrowing EMT6 tumor.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|