Linked Life Data

7094432

Source:http://linkedlifedata.com/resource/pubmed/id/7094432

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-9-24
pubmed:abstractText
1. The perfused guinea-pig lung in vitro released a total of 290 +/- 24 nmol choline after 65 min. At the end of perfusion, there were 525 +/- 36 nmol choline and 11.6 +/- 0.5 mg lecithin per g of lung tissue. 2. When perfused with 1:2-(14) C-choline at 20 nmol (20 nCi)/ml for 70 min, the level of choline in the perfusion fluid remained at 20 nmol/ml; but 65% of radioactivity was abstracted by the lung. 21% of the sequestered radioactivity was in choline phospholipids, chiefly lecithin. 3. The p-terphenyl analogue of hemicholinium no. 3 (TPHC-3), when added into the perfusion fluid at concentration 30 nmol/ml, increased significantly both the 14C-choline uptake and the conversion of 14C-choline to 14C-lecithin in the lung. However, it did not change the total tissue concentration of choline and lecithin in the lung. 4. The lung seems to have separate uptake and release mechanisms for choline and these are in equilibrium. 5. The effects of TPHC-3 on the lung in this study may be secondary to its respiratory depressant action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0305-1870
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Uptake of 1:2-14C-choline by the guinea-pig lung in vitro: and the effects of p-terphenyl hemicholinium-3.
pubmed:publicationType
Journal Article, In Vitro