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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1982-4-12
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pubmed:abstractText |
Thirty-eight healthy subjects were given single oral doses of debrisoquine and sparteine in a crossover study. The close correlation between urinary metabolic ratios of the two drugs (rs = 0.91; P less than 0.001) demonstrates that the polymorphic N-oxidation of sparteine and 4-hydroxylation of debrisoquine are related pharmacogenetic entities; the metabolism of the two drugs is regulated by identical or closely related genetic factors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0009-9236
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
184-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7056024-Adult,
pubmed-meshheading:7056024-Debrisoquin,
pubmed-meshheading:7056024-Female,
pubmed-meshheading:7056024-Humans,
pubmed-meshheading:7056024-Isoquinolines,
pubmed-meshheading:7056024-Male,
pubmed-meshheading:7056024-Middle Aged,
pubmed-meshheading:7056024-Oxidation-Reduction,
pubmed-meshheading:7056024-Pharmacogenetics,
pubmed-meshheading:7056024-Sparteine
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pubmed:year |
1982
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pubmed:articleTitle |
Polymorphic oxidation of sparteine and debrisoquine: related pharmacogenetic entities.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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