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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1982-9-10
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pubmed:abstractText |
JC virus (JCV)-induced T antigen developed in the nuclei of approximately 50% of adult human brain (AHB) cells infected with JCV. Approximately 10% of these T antigen-positive cells contained glial fibrillary acidic protein (GFAP) and were identified as astrocytes in immunofluorescence studies. About 50% of these T antigen-positive cells bound antiserum to fibronectin on their surface and were identified as fibroblasts. No cells binding antiserum to galactocerebroside (GC), an oliodendrocyte-specific marker, were detected in infected or non-infected AHB cultures. the cell type of AHB that constitutes the remaining 40-50% of T antigen-positive cells that are GFAP-, fibronectin- and GC-negative remains to be determined.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-510X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-96
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7047685-Adult,
pubmed-meshheading:7047685-Antigens,
pubmed-meshheading:7047685-Antigens, T-Independent,
pubmed-meshheading:7047685-Astrocytes,
pubmed-meshheading:7047685-Brain,
pubmed-meshheading:7047685-Culture Techniques,
pubmed-meshheading:7047685-Fibroblasts,
pubmed-meshheading:7047685-Fibronectins,
pubmed-meshheading:7047685-Fluorescent Antibody Technique,
pubmed-meshheading:7047685-Galactosylceramides,
pubmed-meshheading:7047685-Glial Fibrillary Acidic Protein,
pubmed-meshheading:7047685-Humans,
pubmed-meshheading:7047685-Nerve Tissue Proteins,
pubmed-meshheading:7047685-Papillomaviridae,
pubmed-meshheading:7047685-Polyomaviridae
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pubmed:year |
1982
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pubmed:articleTitle |
Demonstration of JC virus by immunofluorescence in multiple cell types in experimentally infected adult human brain cell cultures.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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