Linked Life Data

6965829

Source:http://linkedlifedata.com/resource/pubmed/id/6965829

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-5-30
pubmed:abstractText
The elastase-like activities in whole cell extracts of neutrophilic polymorphonuclear leukocytes of 10 emphysematous patients with alpha 1-antitrypsin deficiency (PiZ) and of 7 subjects with alpha 1-antitrypsin deficiency (PiZ or PiSZ) without emphysema were the same as the activities of healthy nondeficient subjects (PiMM) matched according to age, sex, and smoking history. In 16 emphysematous patients without alpha 1-antitrypsin deficiency (PiMM) however, the leukocyte elastase-like activity tended to be higher than that of normal control subjects. We concluded that in persons with alpha 1-antitrypsin deficiency, the leukocyte elastase-like activity is not a deciding factor in the development of emphysema. In persons without alpha 1-antitrypsin deficiency, however, the leukocyte elastase-like activity may be a contributing factor in the development of this disease. Variations in specific anti-leukocyte-elastase-like activity of alpha 1-antitrypsin, which might play a role in the pathogenesis of emphysema, were not found.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-61
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
A matched-pair study of the leukocyte elastase-like activity in normal persons and in emphysematous patients with and without alpha 1-antitrypsin deficiency.
pubmed:publicationType
Journal Article