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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6316
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pubmed:dateCreated |
1982-6-21
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pubmed:abstractText |
The ability to degrade amyloid A fibrils was studied in the serum of 31 patients with amyloidosis associated with rheumatoid arthritis, 33 patients with rheumatoid arthritis without amyloidosis, and 47 healthy controls. Fibrillar amyloid A protein and the radial diffusion method were used. The mean degrading activity in serum was significantly lower in patients with rheumatoid arthritis complicated by amyloidosis (58 +/- 19% SD of the activity in a pooled sample of sera from 100 healthy blood donors used as standard) than in patients with rheumatoid arthritis alone (78 +/- 14%; p less than 0.001) or controls (99 +/- 19%; p less than 0.001). Alpha 1-antitrypsin, concentrations of which were raised in both groups of patients, inhibited the degrading activity in serum even in low concentrations. A negative correlation between degrading activity and alpha 1-antitrypsin concentrations was observed. These findings suggest that reduced amyloid-A-degrading activity is due to inhibition rather than to deficiency of enzyme.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-103558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-4205522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-47333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-5096367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-5641627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-5723775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-621279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-702058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-7402294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-7441662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802258-949881
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0267-0623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
284
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
617-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6802258-Adult,
pubmed-meshheading:6802258-Amyloid,
pubmed-meshheading:6802258-Amyloidosis,
pubmed-meshheading:6802258-Arthritis, Rheumatoid,
pubmed-meshheading:6802258-C-Reactive Protein,
pubmed-meshheading:6802258-Female,
pubmed-meshheading:6802258-Humans,
pubmed-meshheading:6802258-Male,
pubmed-meshheading:6802258-Middle Aged,
pubmed-meshheading:6802258-Serum Amyloid A Protein,
pubmed-meshheading:6802258-alpha 1-Antitrypsin
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pubmed:year |
1982
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pubmed:articleTitle |
Reduced amyloid-A-degrading activity in serum in amyloidosis associated with rheumatoid arthritis.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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