| pubmed-article:678924 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:678924 | lifeskim:mentions | umls-concept:C0014507 | lld:lifeskim |
| pubmed-article:678924 | lifeskim:mentions | umls-concept:C0025598 | lld:lifeskim |
| pubmed-article:678924 | lifeskim:mentions | umls-concept:C0031404 | lld:lifeskim |
| pubmed-article:678924 | lifeskim:mentions | umls-concept:C0041755 | lld:lifeskim |
| pubmed-article:678924 | pubmed:issue | 6135 | lld:pubmed |
| pubmed-article:678924 | pubmed:dateCreated | 1978-10-25 | lld:pubmed |
| pubmed-article:678924 | pubmed:abstractText | Adverse drug reactions (ADRs) to phenformin and metformin reported to the Swedish Adverse Drug Reaction Committee during 1965--77 were analysed in relation to sales and prescription data. The biguanides accounted for 0.6% of all reported adverse drug reactions but for 6% of the fatal cases (all phenformin). Sixty-four ADRs to phenformin and eight to metformin were classified as causal relation "probable" or "not excluded." Fifty-one of these reactions (71%) were lactic acidosis, all but one being reactions to phenformin. After 1973 phenformin was prescribed less in Sweden and metformin became predominant. A nationwide prescription survey during 1975--6 disclosed no differences in age and sex between patients receiving phenformin and metformin. The mean daily doses prescribed in 1976 were 74 mg of phenformin and 1.5 g of metformin. The numbers of ADRs to the two drugs reported during 1975--7 were related to use. The relative incidences of ADRs reported for phenformin and metformin did not differ. Significantly more cases of lactic acidosis and deaths were reported for phenformin. | lld:pubmed |
| pubmed-article:678924 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678924 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678924 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678924 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678924 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678924 | pubmed:language | eng | lld:pubmed |
| pubmed-article:678924 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678924 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:678924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678924 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:678924 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:678924 | pubmed:issn | 0007-1447 | lld:pubmed |
| pubmed-article:678924 | pubmed:author | pubmed-author:BomanGG | lld:pubmed |
| pubmed-article:678924 | pubmed:author | pubmed-author:BergmanUU | lld:pubmed |
| pubmed-article:678924 | pubmed:author | pubmed-author:WiholmB EBE | lld:pubmed |
| pubmed-article:678924 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:678924 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:678924 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:678924 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:678924 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:678924 | pubmed:pagination | 464-6 | lld:pubmed |
| pubmed-article:678924 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:678924 | pubmed:meshHeading | pubmed-meshheading:678924-H... | lld:pubmed |
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| pubmed-article:678924 | pubmed:meshHeading | pubmed-meshheading:678924-S... | lld:pubmed |
| pubmed-article:678924 | pubmed:meshHeading | pubmed-meshheading:678924-A... | lld:pubmed |
| pubmed-article:678924 | pubmed:meshHeading | pubmed-meshheading:678924-F... | lld:pubmed |
| pubmed-article:678924 | pubmed:meshHeading | pubmed-meshheading:678924-M... | lld:pubmed |
| pubmed-article:678924 | pubmed:meshHeading | pubmed-meshheading:678924-E... | lld:pubmed |
| pubmed-article:678924 | pubmed:meshHeading | pubmed-meshheading:678924-A... | lld:pubmed |
| pubmed-article:678924 | pubmed:meshHeading | pubmed-meshheading:678924-M... | lld:pubmed |
| pubmed-article:678924 | pubmed:meshHeading | pubmed-meshheading:678924-P... | lld:pubmed |
| pubmed-article:678924 | pubmed:meshHeading | pubmed-meshheading:678924-M... | lld:pubmed |
| pubmed-article:678924 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:678924 | pubmed:articleTitle | Epidemiology of adverse drug reactions to phenformin and metformin. | lld:pubmed |
| pubmed-article:678924 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678924 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678924 | lld:pubmed |
