Linked Life Data

6783651

Source:http://linkedlifedata.com/resource/pubmed/id/6783651

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1981-6-23
pubmed:abstractText
Radioiodinated apolipoprotein E, added in small amounts to rat serum, rapidly associates with the serum very low density lipoproteins and high density lipoproteins in proportion to their content of endogenous and apolipoprotein E. The labeled lipoproteins can be separated, without ultracentrifugation, by molecular sieve chromatography. When these labeled lipoproteins are injected intravenously into intact rats, the labeled apolipoprotein E rapidly exchanges with apolipoprotein E in the alternate lipoprotein fraction and is removed from the blood at a slow rate, comparable to that observed for apolipoprotein A-I in similarly labeled high density lipoproteins. No evidence was found for a rapidly turning over component of high density lipoproteins containing apolipoprotein E. When very low density lipoproteins, labeled endogenously with [3H]cholesterol and with radioiodinated apolipoprotein E, are added to perfusates of isolated rat livers, the labeled cholesteryl esters and apolipoprotein E are removed from the perfusate rapidly and at the same rate. Therefore, the slow removal of labeled apolipoprotein E in very low density lipoproteins in vivo is the result of rapid exchange with apolipoprotein E in high density lipoproteins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
256
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3963-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Metabolism of chromatographically separated rat serum lipoproteins specifically labeled with 125I-apolipoprotein E.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.