Linked Life Data

67234

Source:http://linkedlifedata.com/resource/pubmed/id/67234

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1977-6-11
pubmed:abstractText
The rhythmographic technique was used to study the antiarrthythmic and chromotropic effect of intravenous injections of 10 mg of Obsidan (105 patients), of 10 mg of Isoptine (105 patients), and of oral administrations of 120 mg/day of Obsidan (160 patients) and Isoptine (128 patients). All patients demonstrated persistent extrasystole of different genesis against the background of the sinus rhythm. With intravenous injections the antiarrhythmic effect of Obsidan at rest did not differ from that of Isoptine. Under physical exercises Obsidan tended to display a more powerful negative bathmotropic effect. With the oral route of administration Obsidan was more effective both at rest, and under exercises. It produced a distinct negative chromotropic effect, while Isoptine displayed a biphasic effect. The results of automatic detection of the classes of the antiarrhythmic effect of Obsidan as judged by the dynamics of the sinus rhythm characteristics permit to suggest the possibility of using the later for an individual selection of the therapeutic means for extrasystole.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-9040
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
20-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
[Comparison of antiarrhythmic and chronotropic effect of obsidan and isoptine in extrasystole].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract