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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1984-1-7
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pubmed:abstractText |
Twenty five children with chronic idiopathic thrombocytopenic purpura followed from 6-96 months in 7 Italian paediatric departments were treated with high dose immunoglobulin according to a multicentre protocol. Positive responses were observed in 20 of 25 patients (80%) and negative responses in 5 of 25 (20%). On previous steroid treatment 7 of 10 positive responders were steroid resistant and 13 of 15 were steroid dependent. Within four weeks of beginning treatment 16 of 20 patients (80%) relapsed, while 4 of 20 (20%) maintained normal platelet values after 4-12 months' follow up. Statistical analysis of the platelet count on day five of treatment enabled us to divide positive responders into three groups: good, intermediate, and poor. The possible mode of action and clinical application of high dose immunoglobulin are discussed.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1468-2044
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
851-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6685997-Adolescent,
pubmed-meshheading:6685997-Child,
pubmed-meshheading:6685997-Child, Preschool,
pubmed-meshheading:6685997-Chronic Disease,
pubmed-meshheading:6685997-Female,
pubmed-meshheading:6685997-Humans,
pubmed-meshheading:6685997-Immunization, Passive,
pubmed-meshheading:6685997-Male,
pubmed-meshheading:6685997-Platelet Count,
pubmed-meshheading:6685997-Purpura, Thrombocytopenic,
pubmed-meshheading:6685997-Time Factors
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pubmed:year |
1983
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pubmed:articleTitle |
Chronic idiopathic thrombocytopenia treated with immunoglobulin.
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pubmed:publicationType |
Journal Article
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