Linked Life Data

6629964

Source:http://linkedlifedata.com/resource/pubmed/id/6629964

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-12-20
pubmed:abstractText
Afferent inputs to the central neuronal networks responsible for respiratory control can have effects on respiratory output that persist even after cessation of the original stimulus. In adults, carotid sinus nerve (CSN) stimulation activates a central excitatory mechanism which causes prolonged elevation of respiratory output. In newborns, superior laryngeal nerve (SLN) stimulation activates a central inhibitory mechanism which causes prolonged inhibition of respiratory output. The present study was designed to confirm that CSN stimulation in newborns also activates a long-acting central excitatory mechanism and to determine in what way the long-acting excitatory and inhibitory mechanisms interact. Anesthetized, paralyzed, and vagotomized piglets (2-30 days) were studied. Integrated phrenic nerve activity was determined before, during, and after stimulus trials consisting of CSN and SLN stimulation alone or following trials of sequential or simultaneous CSN and SLN stimulation. Respiratory output following CSN stimulation remained elevated and only gradually declined to the base-line value. Respiratory output following SLN stimulation remained depressed and only gradually recovered to the base-line value. One minute after cessation of the sequential trials, the respiratory output was intermediate between that of CSN or SLN stimulation alone at equivalent poststimulus times. We conclude that the central neural mechanisms which mediate the persistent poststimulus effects of CSN and SLN stimulation are independent but that they interact for a prolonged period following simultaneous or sequential activation. In infants, this interaction may effect respiratory stability during episodes of central or obstructive apnea and hypoxia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0161-7567
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1299-304
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Interaction of excitatory and inhibitory respiratory afterdischarge mechanisms in piglets.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't