Linked Life Data

6607843

Source:http://linkedlifedata.com/resource/pubmed/id/6607843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-4-17
pubmed:abstractText
Mature thymus-derived (T) lymphocytes are generally believed to be derived from a bone marrow progenitor cell. Data from studies with animals suggest that the enzyme terminal deoxynucleotidyl transferase (Tdt) is expressed in many T-cell progenitors in bone marrow. In this study we attempted to identify Tdt+ bone marrow cells in man that may be committed to T lineage based on coexpression of Tdt and antigens that have previously been useful in characterization of thymocytes or peripheral-blood T cells. We used a panel of ten monoclonal antibodies against such antigens to analyze Tdt+ bone marrow cells using two-color immunofluorescence. We found that T-cell-associated antigens were not expressed on Tdt+ bone marrow cells and that T cells in bone marrow have a phenotype similar if not identical to peripheral-blood T cells. These results support the hypothesis that many postthymic immunocompetent T cells are found in human marrow. Our results also suggest that if Tdt+ bone marrow cells are committed to T lineage, then the acquisition of mature T-cell-associated antigens is an intrathymic event.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-73
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Double fluorochrome analysis of human bone marrow lymphoid cells: studies with terminal transferase and anti-T-cell monoclonal antibodies.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't