Linked Life Data

6600668

Source:http://linkedlifedata.com/resource/pubmed/id/6600668

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-4-15
pubmed:abstractText
1. Serum contains amyloid A-degrading activity. This activity is markedly reduced in patients with rheumatoid arthritis (RA) complicated by amyloidosis. alpha 1-Antitrypsin inhibits the degradative activity. To test the hypothesis that the activity of this enzyme is regulated by alpha 1-antitrypsin, we determined the concentrations, elastase-inhibitory activity and phenotypes of alpha 1-antitrypsin in 24 RA patients with and in 26 RA patients without amyloidosis. 2. alpha 1-Antitrypsin concentrations and biological activity were significantly increased in both patient groups compared with control subjects, but there was no difference between the two patient groups. 3. All patients who had developed amyloidosis were of the normal protease inhibitor (Pi) MM-phenotype. 4. We conclude that the difference in the amyloid A-degrading activity between RA patients with or without amyloidosis cannot be accounted for by differences in concentration, activity or Pi type of alpha 1-antitrypsin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
453-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
alpha 1-Antitrypsin and reactive systemic amyloidosis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't