Linked Life Data

6541922

Source:http://linkedlifedata.com/resource/pubmed/id/6541922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1984-12-19
pubmed:abstractText
This paper describes the synthesis of 6-carboxy derivatives of 6H-dibenzo[b,d]pyran. These compounds are among the most rigid structures related to clofibrate ever synthesized, which means they have very few possible conformations of relative stability compared with the many for clofibrate. Compound 6H-2-chloro-6-methyl-dibenzo[b,d]pyran-6-carboxylic acid 3g showed very high hypolipidemic activity being 12 times more potent than clofibrate in reducing plasma cholesterol concentration in the hypercholesterolemic rat and 11 times more potent in reducing plasma triglyceride concentration in the normolipemic rat.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
864-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Hypolipidemic activity of some derivatives of 6H-dibenzo[b,d]pyran.
pubmed:publicationType
Journal Article, In Vitro