| pubmed-article:6497838 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6497838 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:6497838 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:6497838 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:6497838 | lifeskim:mentions | umls-concept:C0597361 | lld:lifeskim |
| pubmed-article:6497838 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:6497838 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:6497838 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:6497838 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6497838 | pubmed:dateCreated | 1984-12-7 | lld:pubmed |
| pubmed-article:6497838 | pubmed:abstractText | Even though most of the hepatic binding capacity for mannose-terminated glycoproteins has previously been shown to reside in the hepatocytes (not in the non-parenchymal cells), detailed evidence for the specific uptake of mannose-terminated ligands has been lacking. In the present studies, yeast invertase, a large glycoprotein (Mr 270 000) containing about 50% mannose, was shown to be taken up into hepatocytes by receptor-mediated endocytosis. The uptake was saturable and could be specifically inhibited by mannosides or by a Ca2+ chelator. The asialo-glycoprotein receptor was not involved. The low-Mr (13 000) ligand ribonuclease B, which contains a single high-mannose glycan, was not taken up by hepatocytes; however, it was taken up as fast as invertase by non-parenchymal liver cells. After injection of 131I-invertase into a rat in vivo, about one-half of the labelled protein was recovered in the hepatocytes. On a per-cell basis, each endothelial cell contained 3-4 times as much radioactivity as did the hepatocytes. On fractionation of hepatocytes in sucrose gradients, invertase showed a different intracellular distribution from that of asialo-fetuin, in that invertase moved much faster into that region of the gradient where the lysosomes were recovered. This indicates that invertase and asialo-fetuin are not transported intracellularly by identical mechanisms. | lld:pubmed |
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| pubmed-article:6497838 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6497838 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6497838 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6497838 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6497838 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:6497838 | pubmed:author | pubmed-author:BergTT | lld:pubmed |
| pubmed-article:6497838 | pubmed:author | pubmed-author:TolleshaugHH | lld:pubmed |
| pubmed-article:6497838 | pubmed:author | pubmed-author:BlomhoffRR | lld:pubmed |
| pubmed-article:6497838 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6497838 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6497838 | pubmed:volume | 223 | lld:pubmed |
| pubmed-article:6497838 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6497838 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6497838 | pubmed:pagination | 151-60 | lld:pubmed |
| pubmed-article:6497838 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6497838 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6497838 | pubmed:articleTitle | Uptake of mannose-terminated glycoproteins in isolated rat liver cells. Evidence for receptor-mediated endocytosis in hepatocytes. | lld:pubmed |
| pubmed-article:6497838 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6497838 | pubmed:publicationType | In Vitro | lld:pubmed |
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