Linked Life Data

6491644

Source:http://linkedlifedata.com/resource/pubmed/id/6491644

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-11-30
pubmed:abstractText
Mice were infected by aerosol inhalation with influenza A/PR8/34 virus, and the kinetics of infection were monitored by the measurement of infectious virus, viral neuraminidase activity, and viral antigen as detected by enzyme immunoassay. Pulmonary levels of neuraminidase activity closely paralleled the infectious titers quantitated by standard egg inoculation techniques. Both viral neuraminidase activity and viral antigen increased in a dose-dependent manner during the early stages of the viral infection. After day 5, however, viral neuraminidase activity precipitously declined, whereas viral antigen levels remained elevated at high concentration for up to 60 days. Immunosuppressive treatment with cyclophosphamide resulted in the prolonged maintenance of peak virus titers without any additional increases in viral antigen. Previously infected mice were resistant to reinfection with homologous virus as evidenced by the lack of detectable viral neuraminidase activity and the lack of generation of additional viral antigen. These data define the temporal relationship between levels of infectious virus, neuraminidase activity, and viral antigen in an experimental model of influenza virus infection.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0146-6615
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-90
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Dynamics of viral growth, viral enzymatic activity, and antigenicity in murine lungs during the course of influenza pneumonia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't