Linked Life Data

6490471

Source:http://linkedlifedata.com/resource/pubmed/id/6490471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-11-30
pubmed:abstractText
We tested the hypothesis that humoral factors contribute to the onset of exercise hyperpnea in an electrically induced model of isocapnic exercise in alpha-chloralose-anesthetized dogs. A cannula placed in the inferior vena cava (IVC) permitted hindlimb venous blood to flow either directly to the lungs or through a variable-length extracorporeal circuit. Mean transit times (MTT) of blood from exercising hindlimbs were measured from the arrival at the pulmonary artery of green dye injected into the saphenous vein. Onset of hyperpnea was determined by the half time of the ventilatory response (T 1/2), the time required to reach 50% of the steady-state ventilation. In seven dogs, T 1/2 was directly related to MTT (P less than 0.001), suggesting that blood-borne substances released at the onset of exercise contribute to the hyperpneic response. The T 1/2-MTT relation persisted following L2 cord transection (n = 4), suggesting that intraspinal afferents are not required for this response. Chemoreceptor denervation (n = 4) slowed the onset of exercise hyperpnea but did not alter the T 1/2-MTT relation. In this model of electrically induced "exercise" in which neurogenic influences have been minimized, humoral factors alone may stimulate ventilation sufficiently to produce arterial isocapnia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0161-7567
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
874-80
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Temporal delay of venous blood correlates with onset of exercise hyperpnea.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't