Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1984-11-9
pubmed:abstractText
Plasma noradrenaline (NA) and adrenaline (A) concentrations were determined in different vascular areas in 32 patients with cirrhosis and in nine controls during a right sided heart, liver, and renal vein catheterisation. The patients were divided into four groups: (I) Compensated (without ascites); (II) Recompensated on diuretic treatment because of former ascites; (III) Decompensated (with ascites) without treatment and (IV) Decompensated on diuretic treatment. Median arterial noradrenaline concentrations were 1.48, 1.07, 2.66, 4.14 and 2.50 nmol/l in controls, group I, II, III, and IV, respectively, the three last mentioned values being significantly raised (p less than 0.01). Median arterial adrenaline concentrations were not significantly increased. In patients arterial-hepatic venous extraction ratios of noradrenaline and adrenaline were on the average 25% (p less than 0.01) and 20% (p less than 0.02) less than those of the controls, indicating a slightly reduced splanchnic elimination of catecholamines in cirrhoses. In controls and group I significant renal venous-arterial noradrenaline differences were absent (0.00 and 0.03 nmol/l) while renal venous-arterial noradrenaline differences were significantly increased in groups II, III and IV (0.47, 0.53 and 0.68 nmol/l, p less than 0.01), indicating a significant net release of noradrenaline from the kidneys in recompensated and decompensated patients. Renal extraction of adrenaline was normal. In conclusion, increased arterial noradrenaline in decompensated and recompensated cirrhosis is only to a limited extent owing to reduced net splanchnic elimination. More likely the increase is caused by release of noradrenaline from the kidneys and possibly other organs indicating enhanced sympathetic nervous tone in these conditions.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-13520736, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-13845265, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-13995020, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-14215841, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-14410953, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-16695918, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-329687, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-367719, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-4903077, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-594643, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-6252785, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-6401670, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-6409652, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-6755251, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-6777857, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-6826720, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-6992096, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-7076111, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-716987, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-7199989, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-736138, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-7361588, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-7377345, http://linkedlifedata.com/resource/pubmed/commentcorrection/6479678-7444355
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1034-43
pubmed:dateRevised
2010-9-10
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with decompensated cirrhosis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't