Switch to
Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0015576,
umls-concept:C0018591,
umls-concept:C0019754,
umls-concept:C0024264,
umls-concept:C0032659,
umls-concept:C0441704,
umls-concept:C0449432,
umls-concept:C0599883,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1708726,
umls-concept:C1875307
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pubmed:issue |
1-2
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pubmed:dateCreated |
1981-7-23
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pubmed:abstractText |
Using a number of intrafamilial PLTs raised against identical HLA haplotypes it has been possible to construct a model in an informative family defining the HLA-D region as a genetic system. This system consists of at least two regions separated by a recombination between HLA-D and GLO. In relation to the site of recombination, a minimum of one centromeric and three telomeric components can be identified per haplotype. - Fourteen PLTs raised and defined within the family were subsequently tested in a Caucasian population (n = 84) and in 13 unrelated, complete families. - It is concluded that the hypothetical model proposed for the HLA-D regions as a genetic system of linked loci, coding at the cell surface for associated but distinct components (at least four per haplotype), allows for typing of the components of the HLA-D system of any given haplotype. Serological typing of HLA-D components should, in the near future, provide a more convenient way of establishing component phenotypes than the present use of primed lymphocyte typing reagents. Among the components isolated, some have a high association with the classic alleles defined either by homozygous typing cells or DR serology. Others form the basis of cross-reactivity but their presence does not interfere with standard typing. Others, however, seem by their mere presence to be responsible for false assignments. - The concept of HLA-D as a genetic system clarifies many of the inconsistencies observed with a one-locus system.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0093-7711
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-84
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6453081-Chromosome Mapping,
pubmed-meshheading:6453081-Family,
pubmed-meshheading:6453081-Female,
pubmed-meshheading:6453081-Haploidy,
pubmed-meshheading:6453081-Histocompatibility Antigens Class II,
pubmed-meshheading:6453081-Histocompatibility Testing,
pubmed-meshheading:6453081-Humans,
pubmed-meshheading:6453081-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:6453081-Lymphocytes,
pubmed-meshheading:6453081-Male,
pubmed-meshheading:6453081-Phenotype,
pubmed-meshheading:6453081-Population
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pubmed:year |
1981
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pubmed:articleTitle |
The HLA-D system: at least two loci and four distinct phenotypic traits per haplotype. Introduction to component typing in families and population by primed lymphocyte typing.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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