Linked Life Data

6441105

Source:http://linkedlifedata.com/resource/pubmed/id/6441105

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-3-14
pubmed:abstractText
Isolated capillary endothelial cells exhibit an enhanced vesicular ingestion of nonenzymatically glucosylated myoglobin and ovalbumin. Proteins were incubated in the presence of glucose and the extent of nonenzymatic glucosylation was assessed using NaB3H4 reduction. Unmodified and glucosylated proteins were fluorescently labeled, and vesicular ingestion was quantified using a system of isolated capillary endothelium. Glucosylated myoglobin exhibited a 3.5-fold greater rate of vesicular injection as compared to unmodified myoglobin during the initial 30 min of ingestion. Glucosylated ovalbumin was vesicularly ingested at a rate 15-fold greater than the rate observed for unmodified ovalbumin during the initial 30 min of ingestion. These results indicate that glucosylation of small proteins may alter their subsequent recognition by the endothelial cell plasma membrane and result in increased sequestration within micropinocytic vesicles.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0026-2862
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-21
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Enhanced vesicular ingestion of nonenzymatically glucosylated proteins by capillary endothelium.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't