|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1983-10-28
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|
pubmed:abstractText |
Proprietary naloxone hydrochloride (Narcan) acts on isolated hepatocytes from 24-h starved rats to increase 14CO2 production from [1-14C]oleate and to reverse in part the inhibitory effect of ethanol on the oxidation of [1-14C]oleate to 14CO2. The effects are attributable not to naloxone itself, but to the methyl p-hydroxybenzoate present in Narcan as a preservative. The question is posed as to whether methyl p-hydroxybenzoate and p-hydroxybenzoate contribute to the reported antagonism by proprietary naloxone of acute ethanol intoxication in vivo.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0006-3002
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
13
|
|
pubmed:volume |
759
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
303-5
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:6411133-Animals,
pubmed-meshheading:6411133-Carbon Dioxide,
pubmed-meshheading:6411133-Ethanol,
pubmed-meshheading:6411133-Female,
pubmed-meshheading:6411133-Ketone Bodies,
pubmed-meshheading:6411133-Liver,
pubmed-meshheading:6411133-Naloxone,
pubmed-meshheading:6411133-Oleic Acid,
pubmed-meshheading:6411133-Oleic Acids,
pubmed-meshheading:6411133-Parabens,
pubmed-meshheading:6411133-Rats,
pubmed-meshheading:6411133-Rats, Inbred Strains
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|
pubmed:year |
1983
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|
pubmed:articleTitle |
Is the direct effect of naloxone on liver cell metabolism an artifact?
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|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
