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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1983-8-11
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pubmed:abstractText |
The effect of intracellular calcium injection on steady state membrane currents was studied in isolated guinea-pig ventricular cells with a single-electrode voltage clamp method. When the membrane potential was clamped at the resting potential, an intracellular injection of Ca induced an inward current. The steady state current-voltage (I-V) curves before and after Ca injection crossed at around -22 mV. Above this potential, Ca increased the current in the outward direction. A linear relationship was observed between the current mediated by the increase of intracellular Ca and membrane potentials from -60 to +10 mV. This current component may correspond to the Ca-activated non-selective cation channels recorded by the patch clamp technique (Colquhoun et al., 1981).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0031-6768
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
397
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6408604-Animals,
pubmed-meshheading:6408604-Calcium,
pubmed-meshheading:6408604-Egtazic Acid,
pubmed-meshheading:6408604-Electrophysiology,
pubmed-meshheading:6408604-Guinea Pigs,
pubmed-meshheading:6408604-Heart,
pubmed-meshheading:6408604-Heart Ventricles,
pubmed-meshheading:6408604-Membrane Potentials
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pubmed:year |
1983
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pubmed:articleTitle |
Effects of intracellular calcium injection on steady state membrane currents in isolated single ventricular cells.
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pubmed:publicationType |
Journal Article,
In Vitro
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