Linked Life Data

6398284

Source:http://linkedlifedata.com/resource/pubmed/id/6398284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
53
pubmed:dateCreated
1985-6-17
pubmed:abstractText
It is generally accepted that cancer induction by organic compounds is a multistage process. Attempts to explain the carcinogenic action of nickel have been limited in scope, and centre around its interaction with nucleic acids, so that only one phase of the initiation process is emphasized. Other possible modes of action of nickel as a carcinogen have not received adequate attention. Classical initiation-promotion experiments employing nickel compounds as either the initiator or the promoter appear to be lacking. Also, little attention has been given to the possible indirect role of nickel as a stabilizer of free radicals formed by the oxidation of various unsaturated molecules including the dienes, cholesterol, and the well-known aromatic carcinogenic hydrocarbons. Other problems to be investigated include the role of nickel, if any, in the enhancement of the kinetics of the formation of ultimate carcinogens from the procarcinogen, or the possible inhibition of the biotransformation of active carcinogens into their inactive conjugates. It will be necessary at all times to carry out control experiments with the so-called inactive metal ions. Without experiments designed specifically to investigate the mechanism of action of nickel as a carcinogen, this topic will continue to remain in the realm of pure speculation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5038
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Mechanism of action of nickel as a carcinogen: needed information.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't