Linked Life Data

6349798

Source:http://linkedlifedata.com/resource/pubmed/id/6349798

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1983-10-28
pubmed:abstractText
Monoclonal antibodies directed against human melanoma and colon carcinoma cells were described essentially by the groups of L.L. Old and K.E. Hellström. Reports dealing with monoclonal antibodies reactive with human lung tumors are still rather rare. Therefore, we used a squamous cell carcinoma line of the lung as immunogen in Balb/c mice and fused the spleen cells of the immunized animals with the X63-AG8.653 mouse myeloma cell line. The clones producing antibodies reactive with squamous cell carcinomas of the lung in an indirect immunofluorescence assay were recloned, and a fine specificity analysis was performed with 44 cultured cell lines of different origin. The data indicated that most of the antigens recognized by these monoclonal antibodies seem to be of embryonic type because of their reactivities with some of the tested human embryonic cell lines. Radioimmunoprecipitation in combination with sodium dodecyl sulfate-polyacrylamide gel electrophoresis is underway to characterize in more detail the antigens recognized by the antisquamous cell lung cancer monoclonal antibodies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-090X
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Monoclonal murine antibodies with specificity for tissue culture lines of human squamous-cell carcinoma of the lung.
pubmed:publicationType
Journal Article