Linked Life Data

6329516

Source:http://linkedlifedata.com/resource/pubmed/id/6329516

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-8-13
pubmed:abstractText
During chronic dietary K+ depletion in rabbits there is a significant reduction of intracellular K+ concentration [( K+]i) in skeletal muscle, but not in the heart. After 1 week of subsequent K+ repletion both plasma [K+] and skeletal muscle [K+]i had returned to control levels. Cardiac muscle on the other hand showed a significant increase in [K+]i above control. It has been suggested that the heart is protected during K+ depletion by some modification to the sarcolemmal Na+ pump. The Na+ pump density was estimated in membrane preparations from normal and K+ depleted rabbits by the specific binding of 3H-ouabain. 3H-ouabain binding in cardiac muscle preparations was increased significantly after 2 weeks of K+ depletion, and remained so for a further 2 weeks of depletion. There was no significant change in 3H-ouabain binding to skeletal muscle preparations after 4 weeks of K+ depletion. After 1 week of subsequent K+ repletion 3H-ouabain binding was still increased in cardiac muscle preparations, corresponding to the overshoot in cardiac muscle [K+]i. These results support the hypothesis that cardiac muscle is protected against K+ loss during chronic K+ depletion by an adaptive increase in Na+ pump density.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0008-6363
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-63
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Adaptation of the cardiac muscle sodium pump to chronic potassium deficiency.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't