Linked Life Data

6316818

Source:http://linkedlifedata.com/resource/pubmed/id/6316818

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1984-1-27
pubmed:abstractText
Systemic and local immune responses were evaluated in dogs given infective canine parvovirus (CPV) and 2 administrations of inactivated CPV 6 months later. Before the inactivated CPV was given, a jejunal cannulation was performed on the animals. During infective CPV administration, concentrations of class-specific copro- and sero-immunoglobulin (Ig)G, IgA, and IgM were determined by enzyme-linked immunosorbent assay. High concentrations of both copro- and sero-IgM, as well as a moderate increase in the concentrations of sero-IgG and copro-IgA, were detected within 3 days after experimental challenge. Hemagglutination inhibition titers correlated with both serum anti-CPV IgG and IgM early and serum anti-CPV IgG in the later states of infection. After 2 oral administrations of inactivated CPV, class-specific jejuno-, copro-, and sero-IgG, IgM, and IgA anti-CPV antibodies also were determined by enzyme-linked immunosorbent assay. High concentrations of jejuno-IgM and moderate levels of jejuno-IgG and IgA were found. Copro-IgM was not detected in the feces; however copro-IgG and IgA were. Also, no correlations were found to exist when sero-IgM and IgG were compared with jejuno- and coproantibody concentrations throughout the experimental period. Thus, it appears that the immune responses to CPV include both a secretory component of the intestinal mucosa and a systemic component of peripheral lymphoid tissues. Application of the modified Witzel's enterostomy to this study of local intestinal immunity proved beneficial. The technique was well tolerated by experimental animals and allowed for simple, multiple sample collections of intestinal contents for virus and antibody determinations with apparently minimal alterations in the luminal environment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9645
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1989-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Systemic and local intestinal antibody response in dogs given both infective and inactivated canine parvovirus.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't