Linked Life Data

6312060

Source:http://linkedlifedata.com/resource/pubmed/id/6312060

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-6
pubmed:dateCreated
1983-11-23
pubmed:abstractText
Rats malnourished since birth and fed a protein-free diet for 2 wk showed almost undetectable levels of liver microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase. Treatment with benzo[a]pyrene rapidly enhanced this activity to levels higher than those observed with untreated normal rats. The carbon-monoxide-reduced cytochrome P-450 spectral peak was shifted from 452 nm in malnourished untreated rats to 448 nm in malnourished benzo[a]pyrene-injected rats and resulted in increases in the intensity of several microsomal protein bands (MW range 46,000-60,000) separated by gel electrophoresis. Malnourished rats then fed with a protein diet exhibited an important increase in aryl hydrocarbon hydroxylase activity, an increase in the intensity of microsomal protein electrophoretic bands (MW range 46,000-60,000), and a shift of the carbon-monoxide-reduced cytochrome P-450 spectral peak from 452 nm to 450 nm. These results suggest that alterations in cytochrome P-450 species related to benzo[a]pyrene metabolism might explain the modulation of this activity by nutritional effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-4108
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
519-33
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Modulation of rat liver aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity by nutritional effects.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't