|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005456,
umls-concept:C0007634,
umls-concept:C0015980,
umls-concept:C0063699,
umls-concept:C0150312,
umls-concept:C0205419,
umls-concept:C0332293,
umls-concept:C0442805,
umls-concept:C0678128,
umls-concept:C2003941,
umls-concept:C2244190
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1983-5-27
|
|
pubmed:abstractText |
The presence of interferon (IFN) receptors on mouse Friend leukemia cells (FLC) has been investigated in binding experiments with highly purified 125I-labeled mouse alpha/beta IFN. Both IFN-resistant clones and wild-type IFN-sensitive FLC showed a specific saturable binding site for mouse IFN with a similar affinity constant. In contrast to IFN-sensitive FLC, IFN-resistant FLC variants were not inducible by IFN for double-stranded RNA-dependent 2-5A synthetase activity.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0042-6822
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
125
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
508-12
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6301152-2',5'-Oligoadenylate Synthetase,
pubmed-meshheading:6301152-Animals,
pubmed-meshheading:6301152-Clone Cells,
pubmed-meshheading:6301152-Friend murine leukemia virus,
pubmed-meshheading:6301152-Interferon Type I,
pubmed-meshheading:6301152-Leukemia, Experimental,
pubmed-meshheading:6301152-Mice,
pubmed-meshheading:6301152-Receptors, Cell Surface,
pubmed-meshheading:6301152-Receptors, Interferon
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
2-5A synthetase activity does not increase in interferon-resistant Friend leukemia cell variants treated with alpha/beta interferon despite the presence of high-affinity interferon receptor sites.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
