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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1982-5-27
|
| pubmed:abstractText |
Reaction of nucleoside phosphorothioates with N-bromosuccinimide in dioxane and H218O leads to the exchange of sulfur for oxygen-18. Using the Sp-isomers of adenosine 5'-O-(1-thiodiphosphate) and adenosine 3',5'-cyclic phosphorothioate, it can be shown by 31P NMR spectroscopy that this reaction proceeds with inversion of configuration yielding the Rp-isomers of [alpha-18O]ADP and [18O]cAMP, respectively. Adenosine 5'-O-(2-thiotriphosphate) and adenosine 5'-O-(3-thiotriphosphate) are likewise converted to [beta-18O]ATP and [gamma-18O]ATP although the stereochemistry of the former reaction has yet to be evaluated. With very slight modifications this reaction is applicable to all the common bases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0021-9258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
257
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3382-4
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:6277935-Adenosine Diphosphate,
pubmed-meshheading:6277935-Chemical Phenomena,
pubmed-meshheading:6277935-Chemistry,
pubmed-meshheading:6277935-Cyclic AMP,
pubmed-meshheading:6277935-Magnetic Resonance Spectroscopy,
pubmed-meshheading:6277935-Oxygen Isotopes,
pubmed-meshheading:6277935-Structure-Activity Relationship,
pubmed-meshheading:6277935-Thionucleotides
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Streospecific substitution of oxygen-18 for sulfur in nucleoside phosphorothioates.
|
| pubmed:publicationType |
Journal Article
|