| pubmed-article:6267282 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6267282 | lifeskim:mentions | umls-concept:C0002072 | lld:lifeskim |
| pubmed-article:6267282 | lifeskim:mentions | umls-concept:C0014898 | lld:lifeskim |
| pubmed-article:6267282 | lifeskim:mentions | umls-concept:C0014996 | lld:lifeskim |
| pubmed-article:6267282 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6267282 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:6267282 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:6267282 | lifeskim:mentions | umls-concept:C0032624 | lld:lifeskim |
| pubmed-article:6267282 | lifeskim:mentions | umls-concept:C0205352 | lld:lifeskim |
| pubmed-article:6267282 | lifeskim:mentions | umls-concept:C0596513 | lld:lifeskim |
| pubmed-article:6267282 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6267282 | pubmed:dateCreated | 1981-10-14 | lld:pubmed |
| pubmed-article:6267282 | pubmed:abstractText | A number of simple silyl enol ethers and vinyl trifluoromethanesulfonates, a relatively new class of organic compounds capable of undergoing alkylation by a nucleophilic addition-elimination process, were evaluated in the P388 lymphocytic leukemia system. No activity (ILS = 8-22%) was observed in the simple vinyl derivatives. Some activity (ILS = 20-42%) was observed for a series of siloxy and sulfonate (CH3SO2 and CF3SO3) functionalized alpha-methylene lactone systems. The enhanced activity of the functionalized systems over the parent methylene lactone is ascribed to a possible irreversible alkylation by cellular nucleophiles via a nucleophilic addition-elimination process. | lld:pubmed |
| pubmed-article:6267282 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6267282 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6267282 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6267282 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6267282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6267282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6267282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6267282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6267282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6267282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6267282 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6267282 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6267282 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:6267282 | pubmed:author | pubmed-author:StangP JPJ | lld:pubmed |
| pubmed-article:6267282 | pubmed:author | pubmed-author:TreptowW LWL | lld:pubmed |
| pubmed-article:6267282 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6267282 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:6267282 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6267282 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6267282 | pubmed:pagination | 468-72 | lld:pubmed |
| pubmed-article:6267282 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6267282 | pubmed:meshHeading | pubmed-meshheading:6267282-... | lld:pubmed |
| pubmed-article:6267282 | pubmed:meshHeading | pubmed-meshheading:6267282-... | lld:pubmed |
| pubmed-article:6267282 | pubmed:meshHeading | pubmed-meshheading:6267282-... | lld:pubmed |
| pubmed-article:6267282 | pubmed:meshHeading | pubmed-meshheading:6267282-... | lld:pubmed |
| pubmed-article:6267282 | pubmed:meshHeading | pubmed-meshheading:6267282-... | lld:pubmed |
| pubmed-article:6267282 | pubmed:meshHeading | pubmed-meshheading:6267282-... | lld:pubmed |
| pubmed-article:6267282 | pubmed:meshHeading | pubmed-meshheading:6267282-... | lld:pubmed |
| pubmed-article:6267282 | pubmed:meshHeading | pubmed-meshheading:6267282-... | lld:pubmed |
| pubmed-article:6267282 | pubmed:meshHeading | pubmed-meshheading:6267282-... | lld:pubmed |
| pubmed-article:6267282 | pubmed:meshHeading | pubmed-meshheading:6267282-... | lld:pubmed |
| pubmed-article:6267282 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6267282 | pubmed:articleTitle | Synthesis and antitumor activity of simple vinyl and alpha-methylene-gamma-butyrolactone sulfonate esters and silyl enol ethers. | lld:pubmed |
| pubmed-article:6267282 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6267282 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:6267282 | lld:chembl |
