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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1981-7-20
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pubmed:abstractText |
Cholinergic neurons which possess mu and delta receptors and/or which are regulated by neurons possessing these receptors, do not appear to have kappa receptors. Only at doses far exceeding (16--32 x) the analgesic ED50 of the prototype kappa antagonist ethylketazocine is acetylcholine turnover depressed in the cortex and hippocampus. This suggests that such activity may involve occupation of mu and/or delta receptors at high doses. The lack of activity of the sigma agonist SKF 10047 also indicates a possible absence of sigma receptors on cholinergic neurons. The partial mu antagonist buprenorphine was found to be a unique narcotic agent in that it behaved as a classical mu agonist at low doses, but as an antagonist at high doses.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0304-3940
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6262686-Acetylcholine,
pubmed-meshheading:6262686-Animals,
pubmed-meshheading:6262686-Brain,
pubmed-meshheading:6262686-Buprenorphine,
pubmed-meshheading:6262686-Male,
pubmed-meshheading:6262686-Morphinans,
pubmed-meshheading:6262686-Naloxone,
pubmed-meshheading:6262686-Organ Specificity,
pubmed-meshheading:6262686-Phenazocine,
pubmed-meshheading:6262686-Rats,
pubmed-meshheading:6262686-Receptors, Opioid
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pubmed:year |
1981
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pubmed:articleTitle |
Actions of kappa, sigma and partial mu narcotic receptor agonists on rat brain acetylcholine turnover.
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pubmed:publicationType |
Journal Article,
Comparative Study
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