Linked Life Data

6262097

Source:http://linkedlifedata.com/resource/pubmed/id/6262097

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-7-20
pubmed:abstractText
Parenchymal strips, isolated from the guinea-pig lung, were stimulated transmurally at different electrical frequencies in vitro. Frequency-response analyses for contraction were obtained on paired strips in the absence or presence of antagonists. Tetrodotoxin was shown to block the effects of electrical stimulation, demonstrating that the contractile response was due to activation of efferent neurons in the tissue. Phentolamine, 10(-5) M, and atropine, 10(-6) M, antagonists demonstrated to be selective for blocking alpha-adrenergic and muscarinic receptors, respectively, produced inhibition of the contractile effects of electrical stimulation. When analyzed at the level of the frequency required to produce a contraction equal to 10% of the maximum produced by histamine, the EF10, the frequency-response curves were shifted 3- to 4-fold to the right by each receptor antagonist. Combination of the two receptor antagonists produced a greater degree of blockade than either alone and, at the maximum frequency utilized (32 Hz), the contractile response did not reach the EF10 in al tissues. Propranolol, 10(-6) M, did not alter the effects of electrical stimulation, but increased the magnitude of contraction produced by exogenously applied norepinephrine. In tissues taken from reserpine-pretreated animals, phentolamine did not produce a statistically significant change in EF10 for electrical stimulation. The data provide evidence that both vascular and airway smooth muscles are present and contribute to contractile responses in the guinea-pig lung parenchymal strip.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Contribution of vascular smooth muscle to contractile responses of guinea-pig isolated lung parenchymal strips.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't