Linked Life Data

6261509

Source:http://linkedlifedata.com/resource/pubmed/id/6261509

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-6-13
pubmed:abstractText
Human thyroid plasma membranes isolated from thyroids from patients with Graves' disease or non-toxic nodular goitres produced, under basal conditions, about 100 pmol cAMP per mg membrane protein in 30 min at 37 degrees C. TSH increased the membrane response from a Graves' thyroid by up to 11-fold. cAMP production with immunoglobulins from patients with Graves' disease was four times that from normal immunoglobulins. The onset of action of thyroid stimulating antibodies (TSAb) was rapid and persisted for 30 min of incubation. A change of incubation buffer from 20 mM to 200 mM Tris-HCl reduced the degree and altered the pattern of immunoglobulin stimulation, whereas maximal TSH stimulation was unchanged. The in vitro interaction between the TSH receptor system and TSAb or TSH will differ according to the conditions used.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0001-5598
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
60-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Activation of membrane-bound adenylcyclase by thyroid stimulating antibodies.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't