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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1981-5-26
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pubmed:abstractText |
The specific activities of the galactose-metabolizing enzymes, galactokinase (EC 2.7.1.6), galactose-1-phosphate uridyltransferase (EC 2.7.7.12), and UDPgalactose 4-epimerase (EC 5.1.3.2), in suckling-rat livers perfused for 90 min with 1 and 4 mM galactose fluctuate significantly with a different pattern of change for each enzyme. Perfusion for 30 min with galactose resulted in a significant increase of transferase specific activity followed by a precipitous decline to about one-fifth of the activity in unperfused liver at 90 min. The increase in transferase activity was also observed when D-glucose was perfused but not when L-glucose, D-fructose, D-xylose, or D-ribose was added to the perfusate. No such changes in transferase activity were observed when adult-rat liver was perfused with galactose. Epimerase activity in the suckling-rat liver was relatively low, and the changes in its activity correlated best with the uptake rate of galactose. The perfused suckling-rat liver may provide a model system for examination of factors that modulate the specific activity of galactose-metabolizing enzymes and effect the metabolism of galactose.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carbohydrate Epimerases,
http://linkedlifedata.com/resource/pubmed/chemical/Galactokinase,
http://linkedlifedata.com/resource/pubmed/chemical/Galactose,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleotidyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/UDPglucose 4-Epimerase,
http://linkedlifedata.com/resource/pubmed/chemical/UTP-Hexose-1-Phosphate...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
240
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
E333-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6259949-Animals,
pubmed-meshheading:6259949-Animals, Suckling,
pubmed-meshheading:6259949-Carbohydrate Epimerases,
pubmed-meshheading:6259949-Female,
pubmed-meshheading:6259949-Galactokinase,
pubmed-meshheading:6259949-Galactose,
pubmed-meshheading:6259949-Liver,
pubmed-meshheading:6259949-Male,
pubmed-meshheading:6259949-Nucleotidyltransferases,
pubmed-meshheading:6259949-Perfusion,
pubmed-meshheading:6259949-Rats,
pubmed-meshheading:6259949-Time Factors,
pubmed-meshheading:6259949-UDPglucose 4-Epimerase,
pubmed-meshheading:6259949-UTP-Hexose-1-Phosphate Uridylyltransferase
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pubmed:year |
1981
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pubmed:articleTitle |
Changing activities of galactose-metabolizing enzymes during perfusion of suckling-rat liver.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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