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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
19
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pubmed:dateCreated |
1980-11-24
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pubmed:abstractText |
Glucagon produces a time- and dose-dependent activation of phospholipid methyltransferase activity in isolated rat hepatocytes. Half-maximal effect is caused by a dose of glucagon of 1 x 10(-10) M. This activation is due to an increase of the Vmax value of the enzyme, without affecting the Km value for S-adenosylmethionine. Exogenous cyclic AMP added to isolated rat hepatocytes mimics the effect of glucagon, and the activation of phospholipid methyltransferase by a nonsaturating concentration of glucagon is spontaneously reversible within 40 min of incubation.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9258
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
255
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9041-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6251072-Animals,
pubmed-meshheading:6251072-Cyclic AMP,
pubmed-meshheading:6251072-Enzyme Activation,
pubmed-meshheading:6251072-Glucagon,
pubmed-meshheading:6251072-Kinetics,
pubmed-meshheading:6251072-Liver,
pubmed-meshheading:6251072-Methyltransferases,
pubmed-meshheading:6251072-Phosphatidyl-N-Methylethanolamine N-Methyltransferase,
pubmed-meshheading:6251072-Phosphatidylethanolamine N-Methyltransferase,
pubmed-meshheading:6251072-Rats,
pubmed-meshheading:6251072-Sodium Fluoride
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pubmed:year |
1980
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pubmed:articleTitle |
Activation of phospholipid methyltransferase by glucagon in rat hepatocytes.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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