|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1982-12-18
|
|
pubmed:abstractText |
Human placental plasma membrane vesicles were cultured for up to 5 days in the presence of spleen cells from (BALB/c X C57BL/6By) F1 hybrid mice. The membrane preparations either inhibited the uptake of [3H]-thymidine ([3H]-TdR) by destroying the viability of the T-cell population or stimulated weak lymphocyte division which was primarily an expansion of the T-cell population. This differential effect was dependent on the membrane concentration in culture and the length of time the membrane preparation had been stored. Membrane preparations that inhibited [3H]-TdR uptake could be converted into stimulatory-type membranes by preincubating them at 37 degrees for several days. This conversion coincided with a change in status concerning membrane susceptibility to disruption by cytotoxic non-T-cells present in the spleen of unimmunized animals. The conversion from stimulating-type membrane into inhibitory-type was never observed. Throughout these cultures the generation of cell-mediated cytolysis could not be detected.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0019-2805
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
469-76
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6215338-Animals,
pubmed-meshheading:6215338-Antilymphocyte Serum,
pubmed-meshheading:6215338-Cells, Cultured,
pubmed-meshheading:6215338-Concanavalin A,
pubmed-meshheading:6215338-Dose-Response Relationship, Immunologic,
pubmed-meshheading:6215338-Female,
pubmed-meshheading:6215338-Humans,
pubmed-meshheading:6215338-Immunity, Cellular,
pubmed-meshheading:6215338-Lymphocyte Activation,
pubmed-meshheading:6215338-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:6215338-Lymphocytes,
pubmed-meshheading:6215338-Mice,
pubmed-meshheading:6215338-Mice, Inbred Strains,
pubmed-meshheading:6215338-Microvilli,
pubmed-meshheading:6215338-Placenta,
pubmed-meshheading:6215338-Pregnancy,
pubmed-meshheading:6215338-Spleen,
pubmed-meshheading:6215338-T-Lymphocytes
|
|
pubmed:year |
1982
|
|
pubmed:articleTitle |
Immune responsiveness against the human placenta. II. Response with xenogeneic lymphocytes in culture.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
