| pubmed-article:6209227 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6209227 | lifeskim:mentions | umls-concept:C0007004 | lld:lifeskim |
| pubmed-article:6209227 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:6209227 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:6209227 | lifeskim:mentions | umls-concept:C0041361 | lld:lifeskim |
| pubmed-article:6209227 | lifeskim:mentions | umls-concept:C2348628 | lld:lifeskim |
| pubmed-article:6209227 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6209227 | pubmed:dateCreated | 1984-12-28 | lld:pubmed |
| pubmed-article:6209227 | pubmed:abstractText | Two monoclonal antibodies (KH-1 and KH-2) against a transplanted fibrosarcoma (KMT-17) in WKA rats were produced by fusing a mouse myeloma (P3-X63-Ag8.653) with spleen cells from syngeneic rats hyperimmunized with KMT-17. Both antibodies showed complement-dependent cytotoxicity against KMT-17. By absorption of cytotoxicity, KH-1 reacted with homologous tumor, other syngeneic fibrosarcomas (KMT-80 and KMT-75), and lung and kidney from normal rats. However, KH-2 reacted with many kinds of tumors and various normal tissues. Antigen specificity was tested by complement fixation and/or solid-phase radioimmunoassay using glycolipids isolated from KMT-17 cells and authentic glycolipids. KH-1 reacted with globotriglycosyl ceramide which was not detected on KMT-17 cells and in cross-reacted weakly with IV3-alpha-galactosyl-lactoneotetraglycosyl ceramide, one of the major glycolipids of KMT-17. The immune reaction was inhibited by alpha-methyl-galactose. KH-2 reacted with lactosyl ceramide and lactoneotetraglycosyl ceramide. The reaction was more potently inhibited by lactose than by beta-methyl-galactose. Antibodies with similar specificity to either KH-1 or KH-2 were elevated in syngeneic rat sera after serial immunization with viable KMT-17 cells. | lld:pubmed |
| pubmed-article:6209227 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6209227 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6209227 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6209227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6209227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6209227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6209227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6209227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6209227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6209227 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6209227 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6209227 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:6209227 | pubmed:author | pubmed-author:ItoMM | lld:pubmed |
| pubmed-article:6209227 | pubmed:author | pubmed-author:SuzukiEE | lld:pubmed |
| pubmed-article:6209227 | pubmed:author | pubmed-author:SendoFF | lld:pubmed |
| pubmed-article:6209227 | pubmed:author | pubmed-author:AraiSS | lld:pubmed |
| pubmed-article:6209227 | pubmed:author | pubmed-author:NaikiMM | lld:pubmed |
| pubmed-article:6209227 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6209227 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:6209227 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:6209227 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6209227 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6209227 | pubmed:pagination | 689-97 | lld:pubmed |
| pubmed-article:6209227 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
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| pubmed-article:6209227 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6209227 | pubmed:articleTitle | Carbohydrates as antigenic determinants of tumor-associated antigens recognized by monoclonal anti-tumor antibodies produced in a syngeneic system. | lld:pubmed |
| pubmed-article:6209227 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6209227 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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